Endocrine Abstracts

During the last couple of years an essential increase of newly diagnosed NENs has been observed, however it should be underlined that many cases represent new challenges for the medical staff. Development of personalized approach to NEN patients on the basis of knowledge rapidly coming from genetic/molecular research, improvement of biochemical/imaging diagnostic methods and availability of more efficient therapeutic options, means that existing guidelines are still being chan...

We present a case of 70 year-old-man, who was referred to the endocrine clinic with incidentally detected 26 mm lesion arising from the left adrenal gland suspicious of pheochromocytoma. This was detected during investigations for asymptomatic microscopic haematuria. He did not describe the typical symptoms of pheochromocytoma (episodic headaches, sweating, tachycardia), but interestingly 4–5 months previously was diagnosed with an acute onset of psychosis with paranoid d...

The aim of the study was to determine the effect of high-fat diets and dietary fatty acids composition on nuclear androgen receptors protein levels (AR) in rat ventral prostate epithelial and stroma part.The study was conducted on 30 male Wistar rats with initial body mass 250±10 g, divided into five groups fed four experimental and one reference diets during three weeks. Experimental semi-synthetic, high-fat (20% w/w) diets were as follows: diet A ...

Background: The influence of hyperinsulinemia and insulin resistance on thyroid function is debatable. Insulin, as an anabolic hormone, may also play a role in thyroid hypertrophy and nodular goitre development. Some recent reports focus on the possible interplay between thyroid function and glucose status in pregnancy, including gestational diabetes mellitus.Aim: The study aimed to assess the relationship between insulin resistance indices and thyroid f...

Composite pheochromocytomas (CP) are rare and constitute 3% of pheochromocytomas. So far, less than 100 cases were described in the literature. We present a case of 60 years old man. He was admitted to ER department due to severe bone pain around chest, ribs and vertebra. CT scan showed expansive, 100x87 mm, non-homogenic left adrenal gland tumour as well as metastatic bone lesions. The 24-hour urinary fractionated metanephrines were significantly elevated - 86195 ug/24h (norm...

Introduction: Over expression of somatostatin receptors (SSTR) is the characteristic feature of well differentiated neuroendocrine neoplasms (NENs). We present two patients with well differentiated NENs of the large intestine with negative SRS and without SSTR expression confirmed with immunohistochemical (IHCH) examination and symptoms of carcinoid syndrome with good clinical response to the therapy with long acting somatostatin analogs.Case reports: 53...

Introduction: Serotonin producing neuroendocrine tumors are usually well differentiated, small lesions localised in the small intestine. Visualisation of the primary tumor might be difficult due to its small size.Case report: A 52 years old man presented with diarrhoea and flushes. Ultrasound examination and computed tomography of the abdomen revealed numerous lesions in the liver. Gastroscopy, colonoscopy and magnetic resonance imaging did not reveal th...

Introduction: Despite development of diagnostic and therapeutic possibilities pancreatic neuroendocrine tumours remain still a clinical challenge.Case report: A 31-year-old woman after cholecystectomy performed in 2007. MRI performed in November 2008 due to abdominal pain revealed tumour of the pancreas – 35×42×32 mm. In May 2009 patient underwent partial excision of the pancreas. On histopathological examination neuroendocrine tumour NET ...

Introduction: Peptide receptor radionuclide therapy is indicated in case of patients with disseminated neuroendocrine tumors and is usually considered as palliative treatment.Case reports: 55 years old man diagnosed with tumor of the pancreatic head. On laparotomy performed in June 2012 tumor was stated unresectable. Histopathological examination revealed the mixed adeno-neuroendocrine cancer (MANEC). Patient was qualified to chemotherapy with gemcitabin...

Introduction: Hashimoto’s thyroiditis (HT) is a complex disease which is caused by genetic as well as environmental factors. While the genetic predisposition to HT has been extensively investigated, the influence of most environmental factors still needs to be evaluated. Based on our previous study, we did not find any correlation between HT and the fact of cigarette smoking or the number of pack-years. We did, however, find a significant correlation between the age of s...